
A little research turned up Chris Eppstein's Compass gem. This is a very nice meta-framework, which can be used with Rails, Merb, Sinatra or other Ruby frameworks as well as pure Ruby, that combines Hampton Caitlin's SASS gem with any of several CSS frameworks, including (at this writing) Blueprint, Yahoo! UI Grids and 960 Grid System. Blueprint seemed sufficient for my needs and the easiest choice so I went with it.